Location: 22 locations, This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study is composed of a safety run-in and an exploratory part. Location: 5 locations, This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease. This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. When this type of abnormal growth occurs in the colon or rectum, it is called colorectal cancer (CRC). It is not yet known whether giving additional treatment with chemotherapy after surgery to patients who test positive for ctDNA and are at low risk for cancer recurrence would extend their time without disease compared to the usual approach (active surveillance). Encorafenib in combination with binimetinib and cetuximab may target the BRAF V600E-mutation in colorectal cancer. Immunotherapy with monoclonal antibodies, such as pertuzumab and cetuximab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Location: 16 locations, CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. Location: 12 locations, Patients will receive intra-tumoral (IT) NKTR-262 in 3-week treatment cycles. Eligible patients will be assigned to one of several treatment arms. Esthenioneuroblastoma (closed to accrual) 44. This year it’s estimated that more than 100,000 new cases of colon cancer and an estimated 44,180 new cases of rectal cancer will be diagnosed in the U.S., according to the American Cancer … Physically and emotionally drained from chemotherapy, she was unable to care for her family the way … Colorectal cancer … The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Due to the nature of this study design, some tumor cohorts may complete enrollment earlier than others. Location: 12 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. Clinical trials … Part 2 of the study will evaluate the antitumor activity of TSR-022, both as monotherapy and in combination with TSR-042 in participants with pre-specified tumor types. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. You may want to think about taking part in a clinical trial. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. During the Phase 1 dose escalation portion of the trial, NKTR-262 will be combined with systemic administration of bempegaldesleukin. Growth factor antagonists, such as regorafenib, may interfere with the growth factor and stop the tumor from growing. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). Location: 16 locations, This study will evaluate the safety profile, tolerability, PK, PD, and preliminary efficacy of BMS-813160 alone or in combination with either chemotherapy or nivolumab in participants with metastatic colorectal and pancreatic cancers. Location: 6 locations, This phase III trial studies how well either FOLFIRI (leucovorin, fluorouracil, and irinotecan), active surveillance, nivolumab, or encorafenib, binimetinib, and cetuximab work in decreasing recurrence (chance of the cancer coming back) in patients with stage III colorectal cancer who are ctDNA positive. It works by attaching to and blocking a molecule called PD-1. Perivascular epithelioid cell tumor (PEComa) 39. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. The vitamin D receptor is found in colon cancer cells. Antibodies that block PD-1 can potentially prevent PD-1 from shutting down the immune system, thus potentially allowing immune cells to recognize and destroy cancer cells. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer. Clinical trials look at new ways to prevent, detect, or treat disease. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Location: 5 locations, This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF). Adenocarcinoma with variants of GU system (excluding prostate cancer) (closed to accrual 07 / 27 / 2018) 21. Part 2 of the study will further evaluate the RP2D in 3 distinct tumor cohorts of approximately 12 subjects each. The COBRA trial, which opened to accrual in December 2019, is expected to enroll over 1,400 patients who have resected stage IIA colon cancer that is considered low-risk and would not … Location: 13 locations, This is a Phase 1 / 1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. Included tumor types (a, b) and regional distribution (c) of clinical PD-1 / PD-L1 and CAR T cell trials in 2019.ClinicalTrials.gov was searched for “pd-l1” OR “pd-1” OR “programmed death ligand” OR “car t cell” OR “chimeric antigen receptor”. Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF). [button] Download the Clinical Trials Mini Magazine [/button] Location: 11 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis 18. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. If you’re wondering what makes a colorectal cancer clinical trial successful, the risks involved in trials and if some of the common myths are true, download the Clinical Trials Mini Magazine and talk it over with your doctor. Pheochromocytoma, malignant (closed to accrual) 25. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Heated intra-peritoneal chemotherapy is a monoclonal antibody that may interfere with the ability of tumor cells according to type. In 3 colon cancer trials 2019 tumor cohorts of approximately 12 subjects each primary ; CuP ) ( closed to accrual 37... Vascular endothelial growth factor ( VEGF ) performed in combination with anti-PD-1 and antibodies! Is a monoclonal antibody that may interfere with the growth of tumor cells by blocking some of study... 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